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Abstract #3356

Hybrid Diffusion Imaging to Detect Acute White Matter Injury after Mild TBI

Sourajit Mitra Mustafi1, Chandana Kodiweera2, Laura A. Flashman3, Thomas W. McAllister4, and Yu-Chien Wu1

1Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 2Department of Psychological and Brain Sciences, Dartmouth College, Dartmouth, NH, United States, 3Department of Psychiatry, Dartmouth Hitchcock Medical Center and New Hampshire Hospital, Lebanon, NH, United States, 4Department of Psychiatry, Indian University School of medicine, Indianapolis, IN, United States

In the present study we used multi-shell Hybrid Diffusion Imaging (HYDI) to study white matter changes in the acute stage of mild traumatic brain injury (mTBI). Nineteen mTBI patients and 23 trauma-controlled subjects were recruited and studied within 1 month of injury. Non-parametric diffusion analysis, q-space imaging as well as parametric analyses including conventional DTI and novel neurite orientation dispersion and density imaging (NODDI) were used to analyze the HYDI data. Only intra-axonal volume fraction of the NODDI model showed significant and diffuse decrease in white matter of the mTBI patients.

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