Abstract #3363

White Matter Integrity In Acute Mild Traumatic Brain Injury: A Diffusion Kurtosis MRI Study

Sohae Chung^1,2, Els Fieremans^1,2, Dmitry S Novikov^1,2, Jacqueline Smith^1,2, Steven R Flanagan³, and Yvonne W Lui^1,2

¹Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, New York University School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, ³Department of Rehabilitation Medicine, New York University Langone Medical Center, New York, NY, United States

Mild traumatic brain injury (mTBI) is a growing public health problem. Most patients recover quickly, but some patients may suffer from serious symptoms. In this study, we investigated white matter (WM) changes in mTBI in terms of compartment specific WM tract integrity (WMTI) metrics derived from diffusion kurtosis imaging (DKI), such as intra-axonal diffusivity (D_axon), extra-axonal axial and radial diffusivities (D_e,a and D_e,r), and axonal water fraction (AWF). The observed decreases in D_axon and D_e,a suggest that increased restrictions along the axons, both inside and outside, such as possible axonal beading, could occur acutely after injury.

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