Abstract #3364

Diffusion tensor imaging analysis to assess stem cell therapy efficacy in traumatic brain injury

Nastaren Abad^1,2, Abdol Aziz O. Ould Ismail^1,2, Ali Darkazali³, Jens T. Rosenberg¹, Cathy Levenson³, and Samuel Colles Grant^1,2

¹Center for Interdisciplinary MR, National High Magnetic Field Laboratory, Tallahassee, FL, United States, ²Chemical & Biomedical Engineering, Florida State University, Tallahassee, FL, United States, ³Biomedical Sciences and Program in Neuroscience, Florida State University, Tallahassee, FL, United States

Traumatic Brain Injury (TBI) interferes with the functionality of the brain due to heterogeneous complications that continue after the initial trauma. As a result, stem cell therapy is viewed as a potential treatment approach that can be instituted during the chronic phase of TBI. This study employs Diffusion Tensor Imaging (DTI) to non-destructively probe the pathological impacts of endogenous Neural Progenitor Cells (NPC) and exogenous Mesenchymal Stem Cells (MSC) in a rodent model of TBI. This study represents the first investigation of the efficacy of MSC treatment in TBI and the potential synergistic effect of MSC and NPC.

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