Abstract #3365

Tract-based longitudinal analysis of microstructural diffusion changes of mild traumatic brain injury in sports

Maged Goubran¹, Wei Bian¹, Brian Boldt¹, Mansi Parekh¹, David Douglas¹, Eugene Wilson¹, Lex Mitchell¹, Scott Anderson², Gerry Grant³, Huy Do¹, and Michael Zeineh¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Sports Medicine, Stanford University, Stanford, CA, United States, ³Department of Neurosurgery, Stanford University, Stanford, CA, United States

While many cross sectional DTI studies have been performed for mild TBI in sports, very few longitudinal investigations have been performed. We present here a large longitudinal study assessing white matter integrity in high vs. low contact sports employing whole brain automated tractography and NODDI. We performed a tract-based analysis at baseline and longitudinally over 3 years, with both experiments localizing diffusion changes along the callosum forceps minor, left thalamic radiation and the superior longitudinal fasciculus. We have also shown that diffusion metrics correlate with cognition as assessed by the SCAT scores.

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