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Abstract #3365

Tract-based longitudinal analysis of microstructural diffusion changes of mild traumatic brain injury in sports

Maged Goubran1, Wei Bian1, Brian Boldt1, Mansi Parekh1, David Douglas1, Eugene Wilson1, Lex Mitchell1, Scott Anderson2, Gerry Grant3, Huy Do1, and Michael Zeineh1

1Department of Radiology, Stanford University, Stanford, CA, United States, 2Sports Medicine, Stanford University, Stanford, CA, United States, 3Department of Neurosurgery, Stanford University, Stanford, CA, United States

While many cross sectional DTI studies have been performed for mild TBI in sports, very few longitudinal investigations have been performed. We present here a large longitudinal study assessing white matter integrity in high vs. low contact sports employing whole brain automated tractography and NODDI. We performed a tract-based analysis at baseline and longitudinally over 3 years, with both experiments localizing diffusion changes along the callosum forceps minor, left thalamic radiation and the superior longitudinal fasciculus. We have also shown that diffusion metrics correlate with cognition as assessed by the SCAT scores.

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