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Abstract #3373

Transient Changes in White Matter Microstructure during Anesthesia

Cheuk Ying Tang1, Victoria X Wang2, Johnny C Ng2, Stacie Deiner3, Rafael O'Halloran2, Patrick McCormick3, Prantik Kundu2, Lazar Fleysher2, Angela Sanchez3, Kleopoulos Steven4, and Mark Baxter5

1Radiology & Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Anesthesiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The effect of general anesthesia was studied in brain white matter of healthy control elderly subjects. DTI measures were compared between awake and general anesthesia conditions. We found significant transient decreases in Fractional Anisotropy and increases in Mean Diffusivities throughout the brain.

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