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Abstract #3372

G-ratio distribution within the healthy population: the effect of age and gender

Mara Cercignani1,2, Giovanni Giulietti3, Nick Dowell4, Matthew Gabel4, Rebecca Broad4, P Nigel Leigh4, Neil Harrison4, and Marco Bozzali3

1Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, 2Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy, 3Santa Lucia Foundation, Rome, Italy, 4Brighton and Sussex Medical School, Brighton, United Kingdom

This paper investigates the variability of the g-ratio (the ratio of the inner to the outer diameter of a myelinated axon) as a function of age and gender in the healthy population. By combining magnetization transfer and diffusion MRI, the mean g-ratio of 20 white matter tracts was estimated, revealing no gender differences, and a systematic increase with age. Righ vs left hemisphere differences were also detected.

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