Abstract #3371

Oral citicoline treatment improves visuomotor response and white matter integrity in the visual pathway after chronic intraocular pressure elevation

Yolandi van der Merwe^1,2, Xiaoling Yang^1,3, Leon C. Ho^1,4, Yu Yu⁵, Christopher K Leung^6,7, Ian P. Conner^2,3, Seong-Gi Kim^1,8, Gadi Wollstein³, Joel S Schuman^2,3, Michael B Steketee³, and Kevin C Chan^1,3

¹Neuroimaging Laboratory, University of Pittsburgh, Pittsburgh, PA, United States, ²Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ³Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Department of Electrical and Electronic Engineering, University of Hong Kong, Hong Kong, China, People's Republic of, ⁵Division of Biomedical Engineering, Hong Kong University of Science and Technology, Hong Kong, China, People's Republic of, ⁶University Eye Center, Hong Kong Eye Hospital, Hong Kong, China, People's Republic of, ⁷Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China, People's Republic of, ⁸Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Kuwon, Korea, Democratic People's Republic of

Glaucoma is a neurodegenerative disease that can cause irreversible blindness. Lowering intraocular pressure (IOP) is currently the only clinically approved treatment method for glaucoma, however the disease may still progress in some patients after lowering IOP. Citicoline has been suggested as a potential therapeutic for neurodegenerative diseases including glaucoma, but its neuroprotective effect remains incompletely understood. In this study, we determined the effects of oral citicoline treatment on visual function and white matter preservation in an experimental glaucoma model. The results show that citicoline treatment slowed the worsening of visual acuity and preserved white matter integrity along the visual pathway

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