Abstract #3370

Axon Loss Detected by Diffusion Basis Spectrum Imaging (DBSI) in the Absence of Atrophy

Tsen-Hsuan Lin¹, Peng Sun¹, Yong Wang^1,2,3,4, and Sheng-Kwei Song^1,3,4

¹Radiology, Washington University School of Medicine, St. Louis, MO, United States, ²Obstertic and Gynecology, Washington University School of Medicine, St. Louis, MO, United States, ³The Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, United States, ⁴Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States

The extent of axonal loss plays a significant role in irreversible neurological impairment in optic nerve crush (ONC). We detected significant 15% axonal loss in the absence of statistically significant atrophy using diffusion basis spectrum imaging (DBSI) 7 days after ONC in mice.

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