Abstract #3369

A simple method to scale the macromolecular pool size ratio for computing the g-ratio in vivo

Mara Cercignani^1,2, Giovanni Giulietti², Nick Dowell¹, Barbara Spano², Neil Harrison¹, and Marco Bozzali²

¹Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, ²Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy

previous work suggested that the myelin volume fraction (MVF) is proportional to the macromolecular pool size ratio, F, derived from Magnetization Transfer (MT). However the proportionality constant seems to be dependent on the specific MT model, and requires histological validation. Here we propose a simple method based to derive such a constant.

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