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Abstract #3368

Characterizing the cortical terminations of the arcuate fasciculus with diffusion microstructure

Kirsten Mary Lynch1, Arthur Toga1, and Kristi Clark1

1USC Mark and Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States

The arcuate fasciculus (AF) is a group of association fibers consisting of 3 subcomponents that link perisylvian language centers in the frontal, temporal, and parietal lobes. The purpose of this study is to characterize the diffusion microstructural properties and functional outcomes of the cortical AF terminations in the right and left hemispheres. Multi-shell diffusion models were used to extract relative compartment densities, which were compared in cortical regions where AF fibers terminated. The results of this study show that perisylvian language centers exhibit differential cytoarchitecture that can be measured with in vivo MRI measures.

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