Abstract #3375

Super-Resolution MR imaging of ex-vivo eye-globe structures at 7T

Se-Hong Oh¹, Stephen E. Jones¹, Arun Singh², and Mark J. Lowe¹

¹Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, ²Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, United States

We demonstrate a high-resolution ex-vivo globe image using 7T. With voxel size of 250μm isotropic resolution, detailed structures of the globe were clearly identified. Our results show that the high-resolution MR imaging is particularly useful in helping to visualize inner structure of eye-globe. Moreover, it is successfully demonstrated the sensitivity to choroidal melanoma. In addition, we have performed MRI scans using human globe specimens to investigate the contribution of fixation to the evolution of T₂ over time and measured SNR changes as function of the number of excitations to gain some insight into the optimal average number.

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