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Abstract #3375

Super-Resolution MR imaging of ex-vivo eye-globe structures at 7T

Se-Hong Oh1, Stephen E. Jones1, Arun Singh2, and Mark J. Lowe1

1Imaging Institute, Cleveland Clinic Foundation, Cleveland, OH, United States, 2Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH, United States

We demonstrate a high-resolution ex-vivo globe image using 7T. With voxel size of 250μm isotropic resolution, detailed structures of the globe were clearly identified. Our results show that the high-resolution MR imaging is particularly useful in helping to visualize inner structure of eye-globe. Moreover, it is successfully demonstrated the sensitivity to choroidal melanoma. In addition, we have performed MRI scans using human globe specimens to investigate the contribution of fixation to the evolution of T2 over time and measured SNR changes as function of the number of excitations to gain some insight into the optimal average number.

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