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Abstract #3378

Macromolecular proton fraction as an ultimate source of brain tissue contrast in ultra-high magnetic fields

Anna V Naumova1,2, Andrey E Akulov3, Alexandr V Romashchenko 3, Oleg B Shevelev 3, Marina Yu Khodanovich 2, and Vasily L Yarnykh 1,2

1Radiology, University of Washington, Seattle, WA, United States, 2National Research Tomsk State University, Tomsk, Russian Federation, 3Institute of Cytology and Genetics, Novosibirsk, Russian Federation

This study provides methodological background for neuroimaging applications of fast 3D MPF mapping in ultra-high magnetic fields and demonstrates that MPF presents the most effective source of high-field brain tissue contrast. Unique contrast features, high spatial resolution, and the capability to provide quantitative information about myelination make MPF mapping an ultimate tool for small animal neuroimaging in high magnetic fields.

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