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Abstract #3379

Whole human brain diffusion MRI at 450µm post mortem with dwSSFP and a specialized 9.4T RF-coil

Francisco Lagos Fritz1, Sean Foxley2, Shubharthi Sengupta1, Robbert Harms1, Svenja Caspers3, Karl Zilles3, Desmond HY Tse1, Benedikt Poser1, Karla L Miller2, and Alard Roebroeck1

1Dept. of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, Netherlands, 2FMRIB Centre, University of Oxford, Oxford, United Kingdom, 3Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany

The investigation of whole human brains post mortem with large bore systems can achieve a resolution considerably superior to that achievable in-vivo. However, the achievable resolutions and contrast are limited, especially for diffusion MRI (dMRI), by gradient performance, non-optimized RF-coils, and RF-field inhomogeneity and decreasing T2 with increasing B0. Here we report on ultrahigh resolution (450µm) diffusion imaging of the whole human brain showing exquisite spatial definition. This is achieved using a specialized 9.4T 8Ch parallel transmit (pTx), 24Ch receive RF-coil and a diffusion weighted steady state free precession (dwSSFP) sequence extended with a kt-points excitation pulse for B1+ homogenization

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