Abstract #3380

Does tau pathology play a role in abnormal iron deposition in Alzheimer’s Disease? A quantitative susceptibility mapping study in the rTg4510 mouse model of Tauopathy

James O'Callaghan¹, Holly Holmes¹, Nicholas Powell¹, Jack Wells¹, Ozama Ismail¹, Ian Harrison¹, Bernard Siow¹, Michael O'Neill², Emily Catherine Collins³, Karin Shmueli⁴, and Mark Lythgoe¹

¹Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ²Eli Lilly & Co. Ltd, Surrey, United Kingdom, ³Eli Lilly and Company, Indianapolis, IN, United States, ⁴Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom

In this work, quantitative susceptibility mapping (QSM) and T2* mapping were used to investigate iron accumulation both in-vivo and ex-vivo in a mouse model of Alzheimer's Disease exhibiting tau pathology for the first time. Magnetic susceptibility increases relative to controls were identified in grey matter and white matter brain regions and may indicate sensitivity to tissue iron content. QSM in this mouse model may therefore provide a non invasive method by which to dissect the relationship between iron and tau pathology in Alzheimer's Disease.

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