Abstract #3381

T2-weighted imaging of substantia nigra pars compacta shows increased iron deposition in ventral lateral tier

Jason Langley¹, Jan Sedlacik², Daniel E Huddleston³, Xiaoping Hu¹, Jens Fiehler², and Kai Boelmans⁴

¹Department of Biomedical Engineering, Emory University & Georgia Tech, Atlanta, GA, United States, ²Department of Neuroradiology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany, ³Department of Neurology, Emory University, Atlanta, GA, United States, ⁴Department of Neurology, University Medical Center Würzburg, Würzburg, Germany

Recent results found that the SN seen in neuromenalnin sensitive MRI and iron sensitive T₂-weighted contrasts is located in disparate spatial positions in controls. Since iron is known to be deposited in the SN after onset of Parkinson's disease(PD), we re-examine iron sensitive measurements with respect to these new findings in this abstract. Specifically, we find that the SN seen in T₂-weighted contrasts is enlarged in inferiorly and medially when compared to controls. Most of this discrepancy happens in the NM SN and we found the overlap to be an incredibly sensitive marker for PD (p<10^-15).

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