Abstract #3382

Association of Brain Iron Deposition in Parkinson’s Disease with Comorbidities of Visual Hallucinations: An ROI-based Quantitative Susceptibility Mapping Study

Darrell Ting Hung Li¹, Edward Sai Kam Hui¹, Queenie Chan², Nailin Yao³, Siew-eng Chua⁴, Grainne M. McAlonan^4,5, Shu Leong Ho⁶, and Henry Ka Fung Mak¹

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²Philips Healthcare, Hong Kong, Hong Kong, ³Department of Psychiatry, Yale University, New Haven, CT, United States, ⁴Department of Psychiatry, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Department of Forensic and Neurodevelopmental Science, King’s College London, London, United Kingdom, ⁶Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

Abnormal iron accumulation in the brain may cause oxidative-stress-induced neurodegeneration, which is one of the hypothesis of nigral cell death in PD. It was also believed that non-motor symptoms of PD patients are associated with the increased of brain iron content. This study examined the iron concentration in several subcortical structures of PD patients with visual hallucinations by using the QSM technique. Higher magnetic susceptibility was observed in the hippocampus of this patient group. The result supported the hypothesis that hippocampal abnormality could induce visuospatial memory impairment which may be the cause of visual hallucination in PD patients.

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