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Abstract #3382

Association of Brain Iron Deposition in Parkinson’s Disease with Comorbidities of Visual Hallucinations: An ROI-based Quantitative Susceptibility Mapping Study

Darrell Ting Hung Li1, Edward Sai Kam Hui1, Queenie Chan2, Nailin Yao3, Siew-eng Chua4, Grainne M. McAlonan4,5, Shu Leong Ho6, and Henry Ka Fung Mak1

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Philips Healthcare, Hong Kong, Hong Kong, 3Department of Psychiatry, Yale University, New Haven, CT, United States, 4Department of Psychiatry, The University of Hong Kong, Hong Kong, Hong Kong, 5Department of Forensic and Neurodevelopmental Science, King’s College London, London, United Kingdom, 6Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

Abnormal iron accumulation in the brain may cause oxidative-stress-induced neurodegeneration, which is one of the hypothesis of nigral cell death in PD. It was also believed that non-motor symptoms of PD patients are associated with the increased of brain iron content. This study examined the iron concentration in several subcortical structures of PD patients with visual hallucinations by using the QSM technique. Higher magnetic susceptibility was observed in the hippocampus of this patient group. The result supported the hypothesis that hippocampal abnormality could induce visuospatial memory impairment which may be the cause of visual hallucination in PD patients.

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