Evaluation of different high-pass filter on the susceptibility in patients Parkinson’s disease and controls
Gerd Melkus1,2, Santanu Chakraborty1,2, and Fahad A Essbaiheen 1,2,3
1Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, 2Radiology, University of Ottawa, Ottawa, ON, Canada, 3King Saud University, Riyadh, Saudi Arabia
Quantitative susceptibility mapping (QSM) was found as a useful method
to evaluate neurodegenerative diseases such as Parkinson’s disease. For QSM reconstruction
background field removed phase data is needed, but for retrospective studies
only high-pass filtered data might be available. In this study we analyzed the
influence of different high-pass filtered phase images on the susceptibility assessment
for volunteers and Parkinson’s disease patients and compared the results to QSM estimation using
background field removed phase data. With
increasing high-pass filter strength consistently
lower susceptibility results, but up to a certain filter strength differences
in susceptibility can still be distinguished.
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