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Abstract #3384

Evaluation of different high-pass filter on the susceptibility in patients Parkinson’s disease and controls

Gerd Melkus1,2, Santanu Chakraborty1,2, and Fahad A Essbaiheen 1,2,3

1Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, 2Radiology, University of Ottawa, Ottawa, ON, Canada, 3King Saud University, Riyadh, Saudi Arabia

Quantitative susceptibility mapping (QSM) was found as a useful method to evaluate neurodegenerative diseases such as Parkinson’s disease. For QSM reconstruction background field removed phase data is needed, but for retrospective studies only high-pass filtered data might be available. In this study we analyzed the influence of different high-pass filtered phase images on the susceptibility assessment for volunteers and Parkinson’s disease patients and compared the results to QSM estimation using background field removed phase data. With increasing high-pass filter strength consistently lower susceptibility results, but up to a certain filter strength differences in susceptibility can still be distinguished.

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