Abstract #3385

Imaging effects of memantine treatment in a mouse model of Huntington disease using evoked and resting-state fMRI

Wei-Tang Chang¹, Fiftarina Puspitasari¹, Ling-Yun Yeow¹, Hui-Chien Tay¹, Marta Garcia Miralles², Katrianne Bethia Koh², Liang-Juin Tan², Mahmoud POULADI^2,3, and Kai-Hsiang Chuang¹

¹SBIC, A*STAR, Singapore, Singapore, ²TLGM, A*STAR, Singapore, Singapore, ³Department of Medicine, National University of Singapore, Singapore, Singapore

Huntington disease (HD) is an incurable neurodegenerative disease. Recently, memantine (MMT) was found to be effective delaying the progression of disease phenotypes in a mouse model of HD. Here we applied resting-state fMRI to evaluate functional connectivity in HD and the MMT treatment effect and its behavioral correlates. The results of forepaw stimulation reduced evoked responses though significance was hampered by large individual variation. Interestingly, functional connectivity outside of DMN, but not within DMN, was decreased by HD. With MMT treatment, the connectivity increased in general. The FC relevant to the behavioral test also showed behavioral correlates.

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