Abstract #3386

Developmental White Matter Alterations in Monkey Brains with Huntington’s Disease

Yuguang Meng¹, Anthony W.S. Chan^2,3, and Xiaodong Zhang^1,3

¹Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, ²Department of Human Genetics, School of Medicine, Emory University, Atlanta, GA, United States, ³Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States

This study examined the developmental changes of white matter integrity in rhesus monkey brains with the HD gene mutation using diffusion tensor imaging (DTI). Widespread developmental alterations are seen in striatum, and the frontal, motor, sensory and visual brain areas. The findings reveal the temporal-spatial evolution of abnormal white matter maturation during the development of the brain with the Huntington’s Disease, and suggest altered neural substrates associated with motor and cognitive dysfunctions in HD patients.

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