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Abstract #3387

Diffusion tensor imaging of the substantia nigra in Parkinson’s disease revisited

Jason Langley1, Daniel E Huddleston2, Michael Merritt1, Xiangchuan Chen1, Rebecca McMurray2, Michael Silver2, Stewart A Factor2, and Xiaoping Hu1

1Department of Biomedical Engineering, Emory University & Georgia Tech, Atlanta, GA, United States, 2Department of Neurology, Emory University, Atlanta, GA, United States

Inconclusive results from prior diffusion tensor imaging-based studies can be attributed to variability in location of regions of interest used to define the substantia nigra and its subcomponents. We apply recent findings from neuromelanin sensitive MRI to standardize regions of interest for the substantia nigra. Differences in fractional anisotropy and mean diffusivity were found in the neuromelanin sensitive substantia nigra but not in the substantia nigra defined in the b0 image.

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