Abstract #3388

Diagnosis of Parkinsonism Using Nigrosome 1 Imaging at 3T: Comparison of Interobserver Agreement between GRE Magnitude Images (MEDIC) and Susceptibility Map-weighted Images (SMWI)

Eung Yeop Kim¹, Yoon Ho Nam², Young Noh³, Young Hee Sung³, Byeong Ho Goh¹, Joon Hyung Ann¹, and Jongho Lee⁴

¹Radiology, Gachon University Gil Medical Center, Incheon, Korea, Republic of, ²Radiology, Seoul St. Mary Hospital, Seoul, Korea, Republic of, ³Neurology, Gachon University Gil Medical Center, Incheon, Korea, Republic of, ⁴Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

Susceptibility map-weighted imaging (SMWI) improves both CNR and SNR in comparison with conventional SWI. In this work, we compared SMWI with MEDIC (a multi-echo GRE imaging that combines magnitude images via sum of squares) for nigrosome 1 imaging at 3T in terms of interobserver agreement and diagnostic performance in 74 subjects (44 with Parkinson’s disease). Two experienced and two less-experienced reviewers visually assessed both imaging sets separately. Compared with MEDIC, SMWI showed higher kappa values and larger AUCs, regardless of level of experience. As a result, nigrosome 1 imaging using SMWI significantly improved diagnostic performance as well as interobserver agreement.

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