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Abstract #3388

Diagnosis of Parkinsonism Using Nigrosome 1 Imaging at 3T: Comparison of Interobserver Agreement between GRE Magnitude Images (MEDIC) and Susceptibility Map-weighted Images (SMWI)

Eung Yeop Kim1, Yoon Ho Nam2, Young Noh3, Young Hee Sung3, Byeong Ho Goh1, Joon Hyung Ann1, and Jongho Lee4

1Radiology, Gachon University Gil Medical Center, Incheon, Korea, Republic of, 2Radiology, Seoul St. Mary Hospital, Seoul, Korea, Republic of, 3Neurology, Gachon University Gil Medical Center, Incheon, Korea, Republic of, 4Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of

Susceptibility map-weighted imaging (SMWI) improves both CNR and SNR in comparison with conventional SWI. In this work, we compared SMWI with MEDIC (a multi-echo GRE imaging that combines magnitude images via sum of squares) for nigrosome 1 imaging at 3T in terms of interobserver agreement and diagnostic performance in 74 subjects (44 with Parkinson’s disease). Two experienced and two less-experienced reviewers visually assessed both imaging sets separately. Compared with MEDIC, SMWI showed higher kappa values and larger AUCs, regardless of level of experience. As a result, nigrosome 1 imaging using SMWI significantly improved diagnostic performance as well as interobserver agreement.

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