Abstract #3389

Sensitivity of volumetric MRI and MRS to onset and progression of neurodegeneration

Dinesh K Deelchand¹, James M Joers¹, Adarsh Ravishankar², Tianmeng Lyu³, Uzay Emir^1,4, Diane Hutter¹, Christopher M Gomez⁵, Khalaf O Bushara⁶, Christophe Lenglet¹, Lynn E Eberly³, and Gulin Oz¹

¹Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ²School of Physics and Astronomy, University of Minnesota, Minneapolis, MN, United States, ³Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States, ⁴University of Oxford, Oxford, United Kingdom, ⁵Department of Neurology, University of Chicago, Chicago, IL, United States, ⁶Department of Neurology, University of Minnesota, Minneapolis, MN, United States

The goal of this study was to combine MRS with volumetric MRI to determine the sensitivity of these two techniques to onset and progression of neurodegeneration in patients with early-moderate spinocerebellar ataxia type 1. Subjects were scanned at baseline and followed up at ~18 and ~36 months at 3T. Both MRI and MRS measures were found to be more sensitive to disease progression than standardized clinical scores. This study shows that volumetric MRI was most sensitive to disease progression while MRS might be more sensitive to detect the disease’s early stage.

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