Meeting Banner
Abstract #3396

Aberrant interhemispheric structural and functional connectivity in amyotrophic lateral sclerosis: converging evidences from DTI and resting-state fMRI

Jiuquan Zhang1,2, Bing Ji2,3, Zhihao Li2, Jun Hu4, Jian Wang1, Mingze Xu5, and Xiaoping Hu2

1Department of Radiology, Southwest Hospital, Chongqing, China, People's Republic of, 2Department of Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, GA, United States, 3University of Shanghai for Science & Technology, Shanghai, China, People's Republic of, 4Department of Neurology, Southwest Hospital, Chongqing, China, People's Republic of, 5Department of Biomedical Engineering, Perking University, Beijing, China, People's Republic of

The corpus callosum (CC) involvement is a consistent feature of Amyotrophic lateral sclerosis (ALS), thus suggesting a pathopysiology of reduced interhemispheric neural connectivity. In the current study, we directly examined the interhemispheric functional and structural connectivities in ALS. In terms of functional connectivity, extensive alterations in voxel mirrored homotopic connectivity were found in ALS. With structural connectivity, while there were widespread reductions in DTI metrics, only the fiber probability index through CC subregion III in the ALS patients was significantly decreased compared with the controls. These findings provide further evidence for structural and functional interhemispheric connectivity impairment in ALS.

This abstract and the presentation materials are available to members only; a login is required.

Join Here