Abstract #3396

Aberrant interhemispheric structural and functional connectivity in amyotrophic lateral sclerosis: converging evidences from DTI and resting-state fMRI

Jiuquan Zhang^1,2, Bing Ji^2,3, Zhihao Li², Jun Hu⁴, Jian Wang¹, Mingze Xu⁵, and Xiaoping Hu²

¹Department of Radiology, Southwest Hospital, Chongqing, China, People's Republic of, ²Department of Biomedical Engineering, Emory University & Georgia Institute of Technology, Atlanta, GA, United States, ³University of Shanghai for Science & Technology, Shanghai, China, People's Republic of, ⁴Department of Neurology, Southwest Hospital, Chongqing, China, People's Republic of, ⁵Department of Biomedical Engineering, Perking University, Beijing, China, People's Republic of

The corpus callosum (CC) involvement is a consistent feature of Amyotrophic lateral sclerosis (ALS), thus suggesting a pathopysiology of reduced interhemispheric neural connectivity. In the current study, we directly examined the interhemispheric functional and structural connectivities in ALS. In terms of functional connectivity, extensive alterations in voxel mirrored homotopic connectivity were found in ALS. With structural connectivity, while there were widespread reductions in DTI metrics, only the fiber probability index through CC subregion III in the ALS patients was significantly decreased compared with the controls. These findings provide further evidence for structural and functional interhemispheric connectivity impairment in ALS.

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