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Abstract #3397

Investigation of inter-hemispheric functional connectivity in Parkinson's disease with asymmetric onset using Voxel-Mirrored Homotopic Connectivity

Yong Zhang1, Naying He2, Hua-Wei Lin2, Ajit Shankaranarayanan3, Zhenyu Zhou1, and Fu-Hua Yan2

1MR Research China, GE Healthcare, Beijing, China, People's Republic of, 2Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, People's Republic of, 3GE Healthcare, Menlo Park, CA, United States

This preliminary study used voxel-mirrored homotopic connectivity (VMHC), a novel resting-state fMRI parameter to investigate inter-hemispheric functional connectivity in Parkinson’s Disease (PD) with asymmetric onset. Fifteen left side onset (LPD) patients, sixteen right side onset (RPD) patients and nineteen healthy controls were recruited for comparison. Both of LPD and RPD patients showed decreased VMHC in post-central gyrus responsible for motor functions. The decreased VMHC in the cuneus and middle occipital gyrus in LPD patients might affect visual processing function. For RPD patients, VMHC changes in the middle and superior frontal gyrus could be relevant to advanced cognitive impairment.

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