Abstract #3401

MRI signatures in the brain of patients with PD and iRBD

Silvia Mangia¹, Philip Burton¹, Alena Svatkova^2,3, Igor Nestrasil⁴, Alejandra Sierra Lopez⁵, Karin Shmueli⁶, Lynn Eberly⁷, Michael Howell⁴, Paul Tuite⁴, and Shalom Michaeli¹

¹CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ²Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States, ³Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic, ⁴Department of Neurology, University of Minnesota, Minneapolis, MN, United States, ⁵A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ⁶Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁷Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States

The idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson’s disease (PD), therefore by monitoring iRBD one can track the neurodegeneration of individuals that may progress to PD. Here we used a battery of MRI contrasts to characterize brain tissue properties such as microstructural integrity, iron loads, and functional connectivity in 10 iRBD, 10 PD and 10 age-matched healthy subjects. Rotating frame relaxation methods adiabatic T_1,2ρ and RAFFn, along with DTI and rsfMRI detected heterogeneous abnormalities in several subcortical structures of PD and iRBD subjects.

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