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Abstract #3401

MRI signatures in the brain of patients with PD and iRBD

Silvia Mangia1, Philip Burton1, Alena Svatkova2,3, Igor Nestrasil4, Alejandra Sierra Lopez5, Karin Shmueli6, Lynn Eberly7, Michael Howell4, Paul Tuite4, and Shalom Michaeli1

1CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States, 3Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic, 4Department of Neurology, University of Minnesota, Minneapolis, MN, United States, 5A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 6Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 7Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States

The idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson’s disease (PD), therefore by monitoring iRBD one can track the neurodegeneration of individuals that may progress to PD. Here we used a battery of MRI contrasts to characterize brain tissue properties such as microstructural integrity, iron loads, and functional connectivity in 10 iRBD, 10 PD and 10 age-matched healthy subjects. Rotating frame relaxation methods adiabatic T1,2ρ and RAFFn, along with DTI and rsfMRI detected heterogeneous abnormalities in several subcortical structures of PD and iRBD subjects.

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