Abstract #3402

A High b-Value Diffusion Study of Brainstem Abnormality in Patients with Parkinson's Disease Using a CTRW Model

Zheng Zhong^1,2, Muge Karaman¹, Douglas Merkitch³, Jennifer Goldman³, and Xiaohong Joe Zhou^1,4

¹Center for MR Research, Chicago, IL, United States, ²Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ³Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, ⁴Radiology, Neurosurgery and Bioengineering, University of Illinois Hospital & Health Sciences system, Chicago, IL, United States

It has been known that the substantia nigra of brain stem shows structural abnormalities with the progression of Parkinson’s disease. While high b-value diffusion imaging has the potential to reveal such structural changes, single-shot EPI suffers from unwanted geometric distortion which may result in poor analysis of the diffusion data. In this study, we use a recently developed reduced field of view imaging technique and analyze the abnormalities occurring in the substantia nigra of the Parkinson’s disease patients by using the continuous-time random-walk (CTRW) model.

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