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Abstract #3402

A High b-Value Diffusion Study of Brainstem Abnormality in Patients with Parkinson's Disease Using a CTRW Model

Zheng Zhong1,2, Muge Karaman1, Douglas Merkitch3, Jennifer Goldman3, and Xiaohong Joe Zhou1,4

1Center for MR Research, Chicago, IL, United States, 2Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 3Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, 4Radiology, Neurosurgery and Bioengineering, University of Illinois Hospital & Health Sciences system, Chicago, IL, United States

It has been known that the substantia nigra of brain stem shows structural abnormalities with the progression of Parkinson’s disease. While high b-value diffusion imaging has the potential to reveal such structural changes, single-shot EPI suffers from unwanted geometric distortion which may result in poor analysis of the diffusion data. In this study, we use a recently developed reduced field of view imaging technique and analyze the abnormalities occurring in the substantia nigra of the Parkinson’s disease patients by using the continuous-time random-walk (CTRW) model.

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