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Abstract #3403

The Effect of Primidone on Gamma-Aminobutyric Acid Concentration in the Dentate Nucleus in Patients with Essential Tremor

Ulrike Dydak1,2, Ruoyun Ma1,2, Nora Hernandez3, Johnathan P Dyke4, and Elan Louis3,5,6

1School of Health Sciences, Purdue University, West Lafayette, IN, United States, 2Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, 3Department of Neurology, Yale School of Medicine, New Heaven, CT, United States, 4Department of Radiology, Weill Cornell Medical College, New York, NY, United States, 5Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, New Heaven, CT, United States, 6Department of Chronic Disease Epidemiology, Yale School of Public Health, New Heaven, CT, United States

Whether current use of the medication primidone affects dentate γ-aminobutyric acid (GABA) concentrations is unknown. Yet, this may be an important confounder in studies of the pathophysiology of essential tremor (ET). Using the MEGA-PRESS J-editing sequence, we found no difference in dentate GABA levels between patients taking primidone and patients not taking primidone. Furthermore, there was no association between daily primidone dose and dentate GABA concentration. These data suggest that it is not necessary to exclude ET patients on primidone from MRS studies of dentate GABA concentration.

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