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Abstract #3404

Ex-Vivo Diffusion Anisotropy of Human Brain Hemispheres

Yingjuan Wu1, Robert J. Dawe2, Arnold Moya Evia2, Julie A. Schneider3, David A. Bennett3, and Konstantinos Arfanakis2

1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Department of Biomedical Engineering, Illinois Institute of Technology, chicago, IL, United States, 3Rush Alzheimer's Disease Center, Rush University Medical Center, chicago, IL, United States

The aims of this work were to: 1) longitudinally assess the diffusion anisotropy of various white matter regions measured with ex-vivo MRI, and 2) investigate the relationship between FA values measured in-vivo and ex-vivo on the same subjects. This work demonstrated that brain white matter diffusion anisotropy measured ex-vivo decreases with time postmortem, and that diffusion anisotropy measured ex-vivo is linearly related to the diffusion anisotropy measured in-vivo on the same subjects. Combination of ex-vivo MR diffusion anisotropy and histopathology may become an effective tool for the assessment of the neuropathologic correlates of structural brain abnormalities observed in-vivo.

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