Abstract #3405

Faster brain atrophy is associated with accelerated cognitive decline in healthy older adults: the Singapore Longitudinal Ageing Brain Study

June Chi-Yan Lo¹, Ruth Li-Fang Leong¹, Jesisca Tandi¹, and Michael Wei-Liang Chee¹

¹Center for Cognitive Neuroscience, Duke-NUS Graduate Medical School, Singapore, Singapore

Although East Asia harbors the largest number of aging adults in the world, there is limited data on longitudinal changes in brain structure and its relationship with domain-specific cognition. We tracked changes in brain volume and 5 cognitive functions over 8 years among healthy older adults in the Singapore-Longitudinal Aging Brain Study. After adjusting for intracranial volume, demographic factors, and blood pressure, total cerebral atrophy was associated with faster decline in verbal memory. Hippocampal atrophy and ventricular expansion were associated with greater decline in verbal memory and executive functions. These findings clarify the relationships between age-trends in neurobiology and cognition.

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