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Abstract #3406

Age-related alterations in glutamatergic neurotransmission in the anterior and posterior cingulate cortices

Pui Wai Chiu1, Edward S Hui1, Queenie Chan2, Raja Rizal Azman Raja Aman3, Raymond Chuen Chung Chang4, Raymond Chor Kiu Chan5, Leung Wing Chu6, and Henry Ka Fung Mak1

1Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Philips Healthcare, Hong Kong, Hong Kong, Hong Kong, 3Biomedical Imaging, University of Malaya, Kuala Lumpur, Malaysia, 4School of Biomedical Sciences, The University of Hong Kong, Hong Kong, Hong Kong, 5Neuropsychology and Applied Cognitive Neuroscience Laboratory, Chinese Academy of Sciences, Beijing, China, People's Republic of, 6Medicine, Queen Mary Hospital, Hong Kong, Hong Kong

Glutamatergic neurotransmission has an interesting role in aging. The anterior cingulate cortex(ACC) and posterior cingulate cortex(PCC) are focuses for aging research due to their implicated role in cognition. In this study, proton magnetic resonance spectroscopy was used to investigate the changes in glutamatergic neurotransmission during aging by measuring absolute Glx concentration([Glx]abs) in ACC and PCC in a local Chinese cohort at 3.0T. Significant age-related increases of [Glx]abs in ACC and PCC might indicate age-related alterations in glutamatergic neurotransmission. Significantly higher overall [Glx]abs was found in ACC compared with PCC might be attributed to the abundant glutamatergic neurons in the forebrain.

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