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Abstract #3410

Intra Voxel Incoherent Motion (IVIM) in Brain Regions: a Repeatability and Aging Study

Eric T Peterson1, Natalie M Zahr1,2, Dongjin Kwon1, Matthew Serventi1, Cheshire Hardcastle1, Edith V Sullivan2, and Adolf Pfefferbaum1

1Biosciences, SRI International, Menlo Park, CA, United States, 2Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States

This work investigates the inter- and intra-session repeatability and the effects of age on intra voxel incoherent motion (IVIM) parameters. Atlas registration allowed for parcellation-based region specific brain analysis. A new and robust fitting approach reliably identified the perfusion fraction, diffusion, and pseudo-perfusion parameters from 15 healthy normal volunteers. The results show that IVIM is repeatable and that the perfusion fraction, diffusion, and pseudo-perfusion parameters are significantly higher in older than younger adults in several brain regions, most likely from perivascular CSF infiltration. This work serves to highlight how age is an important factor to consider when using IVIM.

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