Abstract #3410

Intra Voxel Incoherent Motion (IVIM) in Brain Regions: a Repeatability and Aging Study

Eric T Peterson¹, Natalie M Zahr^1,2, Dongjin Kwon¹, Matthew Serventi¹, Cheshire Hardcastle¹, Edith V Sullivan², and Adolf Pfefferbaum¹

¹Biosciences, SRI International, Menlo Park, CA, United States, ²Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States

This work investigates the inter- and intra-session repeatability and the effects of age on intra voxel incoherent motion (IVIM) parameters. Atlas registration allowed for parcellation-based region specific brain analysis. A new and robust fitting approach reliably identified the perfusion fraction, diffusion, and pseudo-perfusion parameters from 15 healthy normal volunteers. The results show that IVIM is repeatable and that the perfusion fraction, diffusion, and pseudo-perfusion parameters are significantly higher in older than younger adults in several brain regions, most likely from perivascular CSF infiltration. This work serves to highlight how age is an important factor to consider when using IVIM.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.