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Abstract #3411

Altered neurochemical profile in the healthy elderly measured via 7 T 1H MRS

Malgorzata Marjanska1, J. Riley McCarten2, Laura Hemmy2, Dinesh K Deelchand1, and Melissa Terpstra1

1University of Minnesota, Minneapolis, MN, United States, 2Minneapolis VA Medical Center, Minneapolis, MN, United States

The goal of this work was to characterize differences in the concentrations of neurochemicals beyond tNAA, tCr, and tCho in the OCC and PCC regions of healthy young and elderly subjects. The key innovation was scanning at ultra-high field (7 T) at very short echo time. The observed differences are consistent with compromised neurons (NAA, NAAG, Glu and GABA), membrane turnover (PE and tCho), oxidative stress (lower GSH in the OCC), inflammation (mIns), altered energy metabolism (tCho and Glc), and changes in large molecules (Mac).

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