Abstract #3412

Frontal GABA concentrations predict cognitive function beyond age-related decline.

Eric C. Porges¹, Adam J. Woods¹, Richard A.E. Edden^2,3, Nicolaas A.J. Puts^2,3, Ashley D. Harris^4,5,6, Amanda Garcia¹, Huaihou Chen^1,7, Damon G. Lamb^1,8, John B. Williamson^1,8, and Ronald A. Cohen¹

¹Aging and Geriatric Research, Institute on Aging, Center for Cognitive Aging and Memory, University of Florida, gainesville, FL, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Kennedy Krieger Institute, FM Kirby Center for Functional Brain Imaging, Baltimore, MD, United States, ⁴Department of Radiology, University of Calgary, Calgary, AB, Canada, ⁵CAIR Program, Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁶Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ⁷Department of Biostatistics, University of Florida, Gainesville, FL, United States, ⁸Brain Rehabilitation and Research Center, Malcom Randall Veterans Affairs Medical Center, Gainesville, FL, United States

GABA levels measured with MRS have been associated with performance in numerous sensory and attention domains. Here we demonstrate in a healthy aging cohort that frontal GABA levels are predictive of general cognitive function. Furthermore, the previously reported age-related decrease in GABA levels continues into advanced age.

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