Abstract #3416

Development and Aging of Superficial White Matter Myelin from Young Adulthood to Old Age: Mapping by Vertex-Based Surface Statistics (VBSS)

Minjie Wu¹, Anand Kumar¹, and Shaolin Yang^1,2,3

¹Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States, ²Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, ³Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States

Using Magnetization transfer imaging (MT) and innovative multimodal analysis approach, the current study vertexwise mapped age-related changes of superficial white matter (SWM) from young adulthood to old age (30-85 years, N = 66). Results demonstrated regionally selective and temporally heterochronologic changes of SWM MTR with age, suggesting that myelin change in SWM occurs at varied paces across the cortex. SWM MTR regions including the rostral middle frontal and parahippocampus followed inverted U-shaped trajectories, with protracted maturation till age 40-50 years and accelerating demyelination after age 60 years, while the primary motor, somatosensory and auditory SWM regions did not show age-related deterioration.

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