Abstract #3417

The relationship between White Matter Hyperintensities volume and cognition in normal ageing women

Rowa Aljondi¹, Patricia Desmond^1,2, Chris Steward^1,2, and Cassandra Szoeke³

¹The University of Melbourne, Melbourne, Australia, ²Department of Radiology, Royal Melbourne Hospital, Melbourne, Australia, ³Department of Medicine, The University of Melbourne, Melbourne, Australia

White Matter Hyperintesities (WMH) lesions on brain magnetic resonance imaging (MRI) are common findings in elderly people and contribute to cognitive impairments. Here we examine volumetric MRI measures of WMH volume in relation to neuropsychological measures of episodic memory, executive function, semantic memory and visuospatial abilities in 116 elderly women, their mean age 69 years. Linear regression analysis showed that greater WMH volume was correlated with lower performance on tests involving measures of executive function and visuospatial abilities. These results help elucidate the pathological process leading to cognitive decline in ageing.

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