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Abstract #3418

Normal aging effect on commissure fibers assessed with template-based tractography

Pin-Yu Chen1,2, Jeng-Min Chiou3, Ya-Fang Yang3, Yu-Ting Chen3, Yu-Ling Chang4, Yu-Chun Lo1, Yu-Jen Chen1, Yung-Chin Hsu1, and Wen-Yih I. Tseng1,2,5

1Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, 2Department of Life Science, National Taiwan University, Taipei, Taiwan, 3Institute of Statistical Sciences, Academia Sinica, Taipei, Taiwan, 4Department of Psychology, National Taiwan University, Taipei, Taiwan, 5Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

This study used template-based diffusion spectrum imaging (DSI) tractography to analyze the microstructural integrity of commissure fiber tracts, and applied functional data statistics to analyze the age effect on the tract integrity. The anterior commissure fibers were highly sensitive to the aging effect across the lifespan. The poster commissure fibers became sensitive to the aging effect after 60 years old. In contrast, the age effect of poster commissure fibers appears to occur after age of 60 years old. In conclusion, our study provides evidences for specific degenerative patterns of the commissure fibers tracts in normal ageing which may serve as a useful reference for neurodegenerative diseases.

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