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Abstract #3419

Coupled changes in hippocampal integrity and cognitive ability in later life

Devasuda Anblagan1,2, Maria C Valdés Hernández1, Stuart J Ritchie2,3, Benjamin S Aribisala1,2, Natalie A Royle1,2, Iona F Hamilton1, David A Dickie1, Susana Muńoz Maniega1, Mark E Bastin1,2, Ian J Deary2,3, and Joanna M Wardlaw1,2

1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, 3Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom

We tested whether there were coupled changes in hippocampal volume, T1, MTR, FA and MD and three broad cognitive domains (Verbal Memory, Working Memory, and Speed) in a large sample of community-dwelling non-demented adults at 73 and 76 years of age. Hippocampal volume, FA, MTR and T1 declined from age 73 to 76, while MD increased with age. Higher baseline MD was correlated with steeper cognitive decline in all three cognitive measures, but individuals with higher MD increases (i.e. more apparent deterioration in tissue integrity) also tended to show increases in Working Memory.

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