Devasuda Anblagan1,2, Maria C Valdés Hernández1, Stuart J Ritchie2,3, Benjamin S Aribisala1,2, Natalie A Royle1,2, Iona F Hamilton1, David A Dickie1, Susana Muńoz Maniega1, Mark E Bastin1,2, Ian J Deary2,3, and Joanna M Wardlaw1,2
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, 3Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
We tested whether there were coupled changes in
hippocampal volume, T1, MTR, FA and MD and three broad cognitive domains (Verbal
Memory, Working Memory, and Speed) in a large sample of community-dwelling
non-demented adults at 73 and 76 years of age. Hippocampal
volume, FA, MTR and T1 declined from age 73 to 76, while MD increased with age.
Higher baseline MD was correlated with steeper cognitive decline in all three
cognitive measures, but individuals with higher MD increases (i.e. more
apparent deterioration in tissue integrity) also tended to show increases in
Working Memory.
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