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Abstract #3424

The impact of HPG-axis activation to the brain morphometry: a combined surface-based and voxel-based study

Di Yang1, Yaxin Zhu1, Wenjing Zhang2, Su Lui2, and Zhihan Yan1

1Department of Radiology, Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China, People's Republic, Wenzhou, China, People's Republic of, 2Department of Radiology, Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China, People's Republic of China, Chengdu, China, People's Republic of

We investigated the impact of HPG-axis activity on brain morphometry. A total number of 52 subjects were recruited and scanned structural MRI.HPG-axis activated girls had less cortical thickness in the left inferiorparietal relative to comparison subjects. Meanwhile, gray matter volume was greater in the left precuneus in the focused group, relative to the control group. We found a positive correlation between circulating FSH and volume after excluded one outlier. This study demonstrates that there is some puberty-related maturation of the brain morphometry that is not confounded by age in the earlier stage of puberty.

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