Abstract #3425

Visceral Adiposity, Inflammation and Cortical Thickness in Midlife

Sonya Kaur¹, Stephanie Oleson¹, Evan Pasha², Carolyn Cassill¹, Hirofumi Tanaka², and Andreana Haley¹

¹Psychology, University of Texas Austin, Austin, TX, United States, ²Kinesiology, University of Texas Austin, Austin, TX, United States

The number of individuals classified as obese or overweight has doubled in the last two decades . In addition to documented effects of obesity on physical health, obesity is also associated with significantly deleterious effects on the brain, including increased risk for dementia. It has been hypothesized that the negative effects of obesity on central nervous system functioning are driven by visceral fat, which is metabolically active. However, the mechanisms behind this relationship are poorly understood. Here, we propose to directly test the role of systemic inflammation as a mediator of the relationship between visceral fat and brain structure in middle aged adults

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