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Abstract #3426

Distinguishing Between Different Aging-Related Cognitive Impairments Using GABA and Glx

Dandan Huang1, Hongyan Ni2, Dan Liu2, and Tianyi Qian3

1First Central Clinical College, Tianjin Medical University, Tianjin, China, People's Republic of, 2Tianjin, China, People's Republic of, 3Beijing, China, People's Republic of

Several previous studies have tried to use MRS to investigate changes in brain function. In this study, we used a MEGA-PRESS sequence to measure the GABA and Glx concentration of normal controls, normal elderly controls, and patients with mild cognitive impairment and Alzheimer's disease. In ACC, the Glx showed significant differences between each groups, and the GABA showed significant aging effects in normal subjects.

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