Abstract #3430

Time-dependent diffusion for assessment of treatment response in GL261 murine glioma model

Olivier Reynaud¹, Jin Zhang¹, Kerryanne Veronica Winters¹, Dmitry Novikov¹, and Sungheon Gene Kim¹

¹Center for Biomedical Imaging, Department of Radiology, NYU School of Medicine, New York, NY, United States

In this study, we investigate the feasibility of using the recently proposed diffusion MRI method, POMACE (Pulsed and Oscillating gradient MRI Assessment of Cell size and Extracellular space) for characterization of tissue changes induced by chemotherapy. Surface-to-volume ratio (S/V), cell size (R_cell) and extracellular space volume fraction (ECS) are estimated prior to and after 5FU and bevacizumab treatment in GL261 murine glioma model. Preliminary results indicate an early ECS decrease two days after 5FU/bevacizumab administration. By combining OGSE and PGSE, POMACE provides non-invasive and quantitative metrics regarding tumor microstructure that can be applied to evaluate treatment response.

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