Abstract #3431

Diffusion Tensor Imaging and Neuropsychological Study: Pilot Findings in HIV Adults

Rajakumar Nagarajan¹, Manoj K Sarma¹, Edward Xu¹, Paul M Macey², Mario Guerrero ³, Vanessa Correa ³, Eric S Daar³, and M.Albert Thomas¹

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States, ³Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, United States

Our current study examined whether neuroimaging abnormalities in HIV infected adults are associated with neuropsychological changes as measured by diffusion tensor imaging (DTI) and HIV Dementia scale (HDS). Several brain regions demonstrated significantly decreased values of fractional anisotropy and mean diffusivity. Also there was a significant decline of HDS scores observed in the construction abilities of HIV infected adults compared to healthy controls. This study indicates that DTI is a sensitive tool for correlating neuroanatomic pathologic features with specific cognitive deficits in patients with HIV infection.

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