Meeting Banner
Abstract #3431

Diffusion Tensor Imaging and Neuropsychological Study: Pilot Findings in HIV Adults

Rajakumar Nagarajan1, Manoj K Sarma1, Edward Xu1, Paul M Macey2, Mario Guerrero 3, Vanessa Correa 3, Eric S Daar3, and M.Albert Thomas1

1Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, 2UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States, 3Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, United States

Our current study examined whether neuroimaging abnormalities in HIV infected adults are associated with neuropsychological changes as measured by diffusion tensor imaging (DTI) and HIV Dementia scale (HDS). Several brain regions demonstrated significantly decreased values of fractional anisotropy and mean diffusivity. Also there was a significant decline of HDS scores observed in the construction abilities of HIV infected adults compared to healthy controls. This study indicates that DTI is a sensitive tool for correlating neuroanatomic pathologic features with specific cognitive deficits in patients with HIV infection.

This abstract and the presentation materials are available to members only; a login is required.

Join Here