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Abstract #3439

Diffusion parameters derived from multi b-value DWI-data as surrogate marker for kidney function

Oliver J. Gurney-Champion1,2, René van der Bel3, Martijn Froeling1,4, C.T. Paul Krediet3, and Aart J. Nederveen1

1Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Radiation Oncology, Academic Medical Center, Amsterdam, Netherlands, 3Internal Medicine, Academic Medical Center, Amsterdam, Netherlands, 4Radiology, University Medical Center Utrecht, Utrecht, Netherlands

In this study, we show the potential of the tri-exponential intravoxel incoherent motion (IVIM) model parameters as surrogates for kidney function. We show (n=8) that f1, f2 and D (fit parameters) changed as function of angiotensin-II dose (0, 0.3, 0.9 and 3 ng/kg/min). The changes in f1 and f2 correlated (correlation coefficient r=0.42 and -0.62; p=0.01 and p<0.001) to changes in effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) deduced from a 125I-thalamate and 131I-hippuran clearing test. Finally, we showed (n=6) high inter-session and intra-session repeatability with coefficients of variation below 15% for all fit parameters.

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