Abstract #3439

Diffusion parameters derived from multi b-value DWI-data as surrogate marker for kidney function

Oliver J. Gurney-Champion^1,2, René van der Bel³, Martijn Froeling^1,4, C.T. Paul Krediet³, and Aart J. Nederveen¹

¹Radiology, Academic Medical Center, Amsterdam, Netherlands, ²Radiation Oncology, Academic Medical Center, Amsterdam, Netherlands, ³Internal Medicine, Academic Medical Center, Amsterdam, Netherlands, ⁴Radiology, University Medical Center Utrecht, Utrecht, Netherlands

In this study, we show the potential of the tri-exponential intravoxel incoherent motion (IVIM) model parameters as surrogates for kidney function. We show (n=8) that f₁, f₂ and D (fit parameters) changed as function of angiotensin-II dose (0, 0.3, 0.9 and 3 ng/kg/min). The changes in f₁ and f₂ correlated (correlation coefficient r=0.42 and -0.62; p=0.01 and p<0.001) to changes in effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) deduced from a ¹²⁵I-thalamate and ¹³¹I-hippuran clearing test. Finally, we showed (n=6) high inter-session and intra-session repeatability with coefficients of variation below 15% for all fit parameters.

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