Abstract #3440

Inter-modality correlation of prostatic microenvironmental tissue stiffness and water diffusivity using quantitative functional imaging techniques.

Hugh Harvey¹, Jeremie Fromageau², Veronica Morgan¹, Liz Bancroft³, Ros Eeles³, Jeff Bamber², and Nandita deSouza¹

¹Radiotherapy & Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom, ²The Institute of Cancer Research, London, United Kingdom, ³Oncogenetics, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom

Location-matched ROI analysis of tissue stiffness (SWE) and water diffusivity (ADC) in 9 normal prostates demonstrated that both techniques can adequately differentiate between peripheral and transitional zonal microenvironments, and that there is a weak negative correlation between tissue stiffness and water diffusivity in the peripheral zone. This suggests that factors such as microvascularity, cell size, extracellular matrix and macromolecules may have a differential effect on tissue stiffness and diffusivity. Transitional zone stiffness is too heterogeneous to demonstrate significant inter-modality correlation.

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