Abstract #3441

Dependence of DTI Measures on SNR in a Multicenter Clinical Trial

Xiaopeng Zhou¹, Ken Sakaie¹, Josef Debbins², Robert Fox¹, and Mark Lowe¹

¹Cleveland Clinic, Cleveland, OH, United States, ²Barrow Neurological Institute, Phoenix, AZ, United States

The dependence of DTI metrics on SNR was investigated in a longitudinal multicenter clinical trial. We presented a combined simulation and experimental analysis of the effect of SNR on DTI measures using 27 scanners over 15 months. Although the dependence of DTI measures on SNR is different for each type of scanner, we demonstrate the inverse relation between mean diffusivity and SNR and FA decreasing slightly with SNR. A sufficient SNR is essential for a reliable estimation of DTI parameters generally and the dependence of DTI measures on SNR should be accounted for or corrected when comparing results among scanners.

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