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Abstract #3442

The effect of brain microbleeds on the structural brain network after stroke

Xiaopei Xu1, Henry KF Mak1, Raja Rizal Azman2, Kui-Kai Lau3, and Edward S Hui1

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2Department of Bio-Medical Imaging, University of Malaya, Kuala, Malaysia, 3Department of Medicine, The University of Hong Kong, Hong Kong, Hong Kong

To explore the influences of brain microbleeds (BMBs) on structural brain network in stroke patients, we used DTI-based tractography and brain network analysis to investigate the brain structural network configuration in stroke patients with and without BMBs. Our results demonstrated disrupted balance between integrated and segregated process in global network, and enhanced specialized functions in stroke patients with BMBs. These findings suggested that the presence of BMBs is related to a disturbed brain network organization with imbalanced integrated and segregated information process ability, and brain network analysis is a sensitive tool to assess the impaired cognition caused by cerebral small vessel disease.

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