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Abstract #3443

DTI Association with Working Memory and Speed in Cognitive Network Pathways

Junyu Guo1, John O. Glass1, JungWon Hyun1, Yimei Li1, Conklin Heather1, Lisa Jacola1, Ching-Hon Pui1, Sima Jeha1, and Wilbrun E. Reddick1

1St Jude Children's Research Hospital, Memphis, TN, United States

We investigate the relationship of structural diffusion tensor imaging (DTI) metrics with working memory and decision speed performance in children treated for acute lymphoblastic leukemia (ALL). We built a core neurocognitive network including a central executive network, a salience network, and subcortical cortex based on previous fMRI findings. We generated structural connectivity pathways based on high-resolution DTI data from the human connectome project, and applied those in ALL patients to quantify DTI measures in each pathway. We found that DTI measures in most pathways were significantly associated with working memory and decision speed performance suggesting an essential structural neurocognitive network.

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