Abstract #3443

DTI Association with Working Memory and Speed in Cognitive Network Pathways

Junyu Guo¹, John O. Glass¹, JungWon Hyun¹, Yimei Li¹, Conklin Heather¹, Lisa Jacola¹, Ching-Hon Pui¹, Sima Jeha¹, and Wilbrun E. Reddick¹

¹St Jude Children's Research Hospital, Memphis, TN, United States

We investigate the relationship of structural diffusion tensor imaging (DTI) metrics with working memory and decision speed performance in children treated for acute lymphoblastic leukemia (ALL). We built a core neurocognitive network including a central executive network, a salience network, and subcortical cortex based on previous fMRI findings. We generated structural connectivity pathways based on high-resolution DTI data from the human connectome project, and applied those in ALL patients to quantify DTI measures in each pathway. We found that DTI measures in most pathways were significantly associated with working memory and decision speed performance suggesting an essential structural neurocognitive network.

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