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Abstract #3446

The negative residuals of diffusion kurtosis model: a study on rat brain imaging

Wei-Cheng Lee1, Sheng-Min Huang 1, Cheng-He Li1, Kung-Chu Ho2, and Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan

The well-behaved residual of a successful fitting model should present as an independent random variable in its histogram, otherwise it will contain structure that is not accounted for in this model. In the study, we found that there are two groups of fitting residuals. And the spatial mapping of these smaller negative pixels reveals that the overestimation of kurtosis model is related to the contribution of vessel signal. Therefore, we proposed a semi-kurtosis model to calculate the restricted diffusion adequately and obtain correct DKI information in these regions with vascular interference.

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