Abstract #3447

Spherical Deconvolution of High-Resolution 7T Whole-Head Diffusion Magnetic Resonance Images shows reduced radial anisotropic diffusion in human primary somatosensory cortex

Ralf Lützkendorf¹, Robin M. Heidemann², Thorsten Feiweier², Michael Luchtmann³, Sebastian Baecke¹, Joern Kaufmann⁴, Joerg Stadler⁵, Eike Budinger⁵, and Johannes Bernarding¹

¹Biometry and Medical Informatics, University of Magdeburg, Magdeburg, Germany, ²Siemens Healthcare GmbH, Erlangen, Germany, ³Department of Neurosurgery, University of Magdeburg, Magdeburg, Germany, ⁴Department of Neurology, University of Magdeburg, Magdeburg, Germany, ⁵Leibniz Institute for Neurobiology, Magdeburg, Germany

Diffusion anisotropy in cortical gray matter (GM) and adjacent white matter (WM) provides microanatomic information about the course of the neuronal structures within GM and when connecting to other brain regions. However, interwoven neuronal fiber orientations and complex folded structures render the analysis difficult. Ultra-high-field diffusion MR imaging (dMRI) overcomes these limitations as the improved SNR allowed acquiring 1.4 mm isotropic voxel with increased diffusion-weighting. Applying constrained spherical deconvolution (1) enabled resolving radial and tangential anisotropic diffusion in cortical gray matter confirming recent reports of reduced radial anisotropy in primary somatosensory cortex as compared to other cortical areas (2).

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