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Abstract #3448

Investigation of diffusion signal behavior at different diffusion times in a human hepatocellular carcinoma xenograft model

Mami Iima1,2, Tomomi Nobashi1, Hirohiko Imai3, Sho Koyasu1, Akira Yamamoto1, Yuji Nakamoto1, Masako Kataoka1, Tetsuya Matsuda3, and Kaori Togashi1

1Department of Diagnostic Imaging and Nuclear Medicine, Graduate Schoolof Medicine, Kyoto University, Kyoto, Japan, 2The Hakubi Center for Advancer Research, Kyoto University, Kyoto, Japan, 3Department of Systems Science, Graduate Schoolof of Informatics, Kyoto University, Kyoto, Japan

The relationship between diffusion time and diffusion parameters in a human hepatocellular carcinoma xenograft mouse model was investigated at 7T. There was an increase in K values and decrease in ADCo values in 27.6ms compared to 9.6 ms. Accordiginly a remarkable difference in a composite index (sADC) was also found. The investigation of the water diffusion behavior at different diffusion times may provide valuable information on the contribution of the different compartments or tissue components to the overall diffusion MRI.

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